REACTION OF ORTHO-LITHIATED N-METHYLBENZAMIDE WITH 1,2-DIKETONES - A NOVEL HIGHLY EFFICIENT ROUTE TO N-METHYLISOQUINOLIN-1-ONES

被引：28

作者：

KISELYOV, AS ^{[1
]}

机构：

[1] GEORGIA STATE UNIV, DEPT CHEM, ATLANTA, GA 30303 USA

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 04期

关键词：

D O I：

10.1016/0040-4039(94)02293-K

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1,2-Diketones were found to react with ortho-lithiated N-methylbenzamide to give diols 4a-g in 59-80% yields. Reaction of diols 4a-g with the system Me(3)SiCl/Nal in MeCN furnished N-methylisoquinolin-1-ones in 84-92% yields.

引用

页码：493 / 496

页数：4

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