ETOMIDATE AND PLASMA ESTERASE-ACTIVITY IN MAN AND EXPERIMENTAL-ANIMALS

被引：10

作者：

CALVO, R

CARLOS, R

ERILL, S

机构：

来源：

PHARMACOLOGY | 1979年 / 18卷 / 06期

关键词：

D O I：

10.1159/000137268

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

No hydrolysis of etomidate in plasma in vitro was detected in samples from man, horse, cow, sheep, guinea pig or white rabbit. Brown rabbits showed a moderate degree of hydrolysis and it was marked in plasma from Wistar rats. In this species, a single enzyme, an aliesterase, participated in the hydrolysis in plasma. Etomidate did not interfere with the hydrolysis of procaine by plasma pseudocholinesterase in man.

引用

页码：294 / 298

页数：5