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PHOSPHATIDIC-ACID AND NOT DIACYLGLYCEROL GENERATED BY PHOSPHOLIPASE-D IS FUNCTIONALLY LINKED TO THE ACTIVATION OF THE NADPH OXIDASE BY FMLP IN HUMAN NEUTROPHILS
被引:165
作者
:
ROSSI, F
论文数:
0
引用数:
0
h-index:
0
机构:
HOSP VERONA,TRANSFUS & IMMUNOHEMATOL SERV,VERONA,ITALY
HOSP VERONA,TRANSFUS & IMMUNOHEMATOL SERV,VERONA,ITALY
ROSSI, F
[
1
]
GRZESKOWIAK, M
论文数:
0
引用数:
0
h-index:
0
机构:
HOSP VERONA,TRANSFUS & IMMUNOHEMATOL SERV,VERONA,ITALY
HOSP VERONA,TRANSFUS & IMMUNOHEMATOL SERV,VERONA,ITALY
GRZESKOWIAK, M
[
1
]
DELLABIANCA, V
论文数:
0
引用数:
0
h-index:
0
机构:
HOSP VERONA,TRANSFUS & IMMUNOHEMATOL SERV,VERONA,ITALY
HOSP VERONA,TRANSFUS & IMMUNOHEMATOL SERV,VERONA,ITALY
DELLABIANCA, V
[
1
]
CALZETTI, F
论文数:
0
引用数:
0
h-index:
0
机构:
HOSP VERONA,TRANSFUS & IMMUNOHEMATOL SERV,VERONA,ITALY
HOSP VERONA,TRANSFUS & IMMUNOHEMATOL SERV,VERONA,ITALY
CALZETTI, F
[
1
]
GANDINI, G
论文数:
0
引用数:
0
h-index:
0
机构:
HOSP VERONA,TRANSFUS & IMMUNOHEMATOL SERV,VERONA,ITALY
HOSP VERONA,TRANSFUS & IMMUNOHEMATOL SERV,VERONA,ITALY
GANDINI, G
[
1
]
机构
:
[1]
HOSP VERONA,TRANSFUS & IMMUNOHEMATOL SERV,VERONA,ITALY
来源
:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
|
1990年
/ 168卷
/ 01期
关键词
:
D O I
:
10.1016/0006-291X(90)91711-Z
中图分类号
:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号
:
071010 ;
081704 ;
摘要
:
It is widely accepted that the activation of the NADPH oxidase of phagocytes is linked to the stimulation of protein kinase C by diacylglycerol formed by hydrolysis of phospholipids. The main source would be choline containing phospholipid via phospholipase D and phosphatidate phosphohydrolase. This paper presents a condition where the activation of the respiratory burst by FMLP correlates with the formation of phosphatidic acid, via phospholipase D, and not with that of diacylglycerol. In fact: 1) in neutrophils treated with propranolol, an inhibitor of phosphatidate phosphohydrolase, FMLP plus cytochalasin B induces a respiratory burst associated with a stimulation of phospholipase D, formation of phosphatidic acid and complete inhibition of that of diacylglycerol. 2) The respiratory burst by FMLP plus cytochalasin B lasts a few minutes and may be restimulated by propranolol which induces an accumulation of phosphatidic acid. 3) In neutrophils stimulated by FMLP in the absence of cytochalasin B propranolol causes an accumulation of phosphatidic acid and a marked enhancement of the respiratory burst without formation of diacylglycerol. 4) The inhibition of the formation of phosphatidic acid via phospholipase D by butanol inhibits the respiratory burst by FMLP. © 1990.
引用
收藏
页码:320 / 327
页数:8
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[J].
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SNYDERMAN, R
[J].
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1988,
85
(05)
: 1549
-
1553
[23]
UHING RJ, 1988, CELLULAR MOL ASPECTS
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共 23 条
[21]
THE O-2(-)-FORMING NADPH OXIDASE OF THE PHAGOCYTES - NATURE, MECHANISMS OF ACTIVATION AND FUNCTION
ROSSI, F
论文数:
0
引用数:
0
h-index:
0
ROSSI, F
[J].
BIOCHIMICA ET BIOPHYSICA ACTA,
1986,
853
(01)
: 65
-
89
[22]
CALCIUM INFLUX STIMULATES A 2ND PATHWAY FOR SUSTAINED DIACYLGLYCEROL PRODUCTION IN LEUKOCYTES ACTIVATED BY CHEMOATTRACTANTS
TRUETT, AP
论文数:
0
引用数:
0
h-index:
0
机构:
DUKE UNIV,MED CTR,HOWARD HUGHES MED INST,DEPT MED,DURHAM,NC 27710
DUKE UNIV,MED CTR,HOWARD HUGHES MED INST,DEPT MED,DURHAM,NC 27710
TRUETT, AP
VERGHESE, MW
论文数:
0
引用数:
0
h-index:
0
机构:
DUKE UNIV,MED CTR,HOWARD HUGHES MED INST,DEPT MED,DURHAM,NC 27710
DUKE UNIV,MED CTR,HOWARD HUGHES MED INST,DEPT MED,DURHAM,NC 27710
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DILLON, SB
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0
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h-index:
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DUKE UNIV,MED CTR,HOWARD HUGHES MED INST,DEPT MED,DURHAM,NC 27710
DUKE UNIV,MED CTR,HOWARD HUGHES MED INST,DEPT MED,DURHAM,NC 27710
DILLON, SB
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0
引用数:
0
h-index:
0
机构:
DUKE UNIV,MED CTR,HOWARD HUGHES MED INST,DEPT MED,DURHAM,NC 27710
DUKE UNIV,MED CTR,HOWARD HUGHES MED INST,DEPT MED,DURHAM,NC 27710
SNYDERMAN, R
[J].
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1988,
85
(05)
: 1549
-
1553
[23]
UHING RJ, 1988, CELLULAR MOL ASPECTS
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