AMINO-ACID PATTERNS IN SCHIZOPHRENIA - SOME NEW FINDINGS

被引：60

作者：

MACCIARDI, F ^{[1
]}

LUCCA, A ^{[1
]}

CATALANO, M ^{[1
]}

MARINO, C ^{[1
]}

ZANARDI, R ^{[1
]}

SMERALDI, E ^{[1
]}

机构：

[1] UNIV MILAN,SCH MED,IST SCI HS RAFFAELE,DEPT CLIN PSYCHIAT,I-20122 MILAN,ITALY

来源：

PSYCHIATRY RESEARCH | 1990年 / 32卷 / 01期

关键词：

amino acids; glutamate; glycine; N-methyl-D- aspartate receptors; Schizophrenia;

D O I：

10.1016/0165-1781(90)90136-S

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Blood concentrations of various amino acids were measured in schizophrenic patients and control subjects. Significantly higher blood concentrations of glycine, glutamate, and serine were found in the schizophrenic patients. Glycine was abnormally elevated in subjects with paranoid or undifferentiated schizophrenia, but not in disorganized patients. Since glutamate, glycine, and serine play a complex role in the regulation of N-methyl-D-aspartate (NMDA) receptors, which are important in the control of normal cognitive processes, we hypothesized that the elevated levels of these amino acids might disrupt the normal functioning of NMDA receptors and might be involved in the pathophysiology of schizophrenia. © 1990.

引用

页码：63 / 70

页数：8