FLUCONAZOLE-RESISTANT CANDIDA IN AIDS PATIENTS

被引：54

作者：

HEINIC, GS

STEVENS, DA

GREENSPAN, D

MACPHAIL, LA

DODD, CL

STRINGARI, S

STRULL, WM

HOLLANDER, H

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT MED,SAN FRANCISCO,CA 94143

[2] UNIV CALIF SAN FRANCISCO,CTR ORAL AIDS,SAN FRANCISCO,CA 94143

[3] SANTA CLARA VALLEY MED CTR,DEPT MED,DIV INFECT DIS,SAN JOSE,CA 95128

[4] STANFORD UNIV,DEPT MED,STANFORD,CA 94305

[5] KAISER PERMANENTE MED CTR,SAN FRANCISCO,CA

来源：

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS | 1993年 / 76卷 / 06期

关键词：

D O I：

10.1016/0030-4220(93)90039-7

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Oropharyngeal candidiasis develops in up to 95% of patients with acquired immunodeficiency syndrome. Oral fluconazole is frequently prescribed for persons who are human immunodeficiency virus-seropositive as initial or suppressive therapy for oropharyngeal and esophageal candidiasis or as suppressive therapy for cryptococcal meningitis. We report two cases of oropharyngeal candidiasis, caused by Candida albicans, which developed in two patients with acquired immunodeficiency syndrome who had taken fluconazole for extended periods. in addition to the clinical resistance we observed, isolates of the organism appeared to be resistant in vitro to fluconazole and ketoconazole.

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收藏

页码：711 / 715

页数：5

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