THE SON GENE ENCODES A CONSERVED DNA-BINDING PROTEIN MAPPING TO HUMAN-CHROMOSOME-21

被引：24

作者：

KHAN, IM

FISHER, RA

JOHNSON, KJ

BAILEY, MES

SICILIANO, MJ

KESSLING, AM

FARRER, M

KAMALATI, T

BULUWELA, L

CARRITT, B

机构：

[1] UNIV LONDON,CHARING CROSS & WESTMINSTER MED SCH,DEPT BIOCHEM,LONDON W6 8RF,ENGLAND

[2] UNIV LONDON,CHARING CROSS & WESTMINSTER MED SCH,DEPT ANAT,LONDON W6 8RF,ENGLAND

[3] UNIV TEXAS,MD ANDERSON CANC CTR,DEPT MOLEC GENET,HOUSTON,TX 77030

[4] ST MARYS HOSP,SCH MED,DEPT BIOCHEM & MOLEC GENET,LONDON W2 1PG,ENGLAND

[5] UNIV LONDON UNIV COLL,GALTON LAB,MRC,HUMAN BIOCHEM GENET UNIT,LONDON NW1 2HE,ENGLAND

[6] ROYAL CANC HOSP,INST CANC RES,HADDOW LABS,SUTTON SM2 5NG,SURREY,ENGLAND

来源：

ANNALS OF HUMAN GENETICS | 1994年 / 58卷

基金：

英国惠康基金;

关键词：

D O I：

10.1111/j.1469-1809.1994.tb00723.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We report the identification and characterization of a clone for the DNA binding protein SON, which we have isolated from a human keratinocyte cDNA library. Using this clone we have found that the SON gene is expressed in different cell types and that homologous sequences can be detected in vertebrate and insect genomic DNA. Using the polymerase chain reaction (PCR) to amplify SON sequences from a panel of somatic cell hybrids we have assigned the gene encoding human SON to chromosome 21. By use of hybrids containing regions of chromosome 21 the localization has been refined to 21q 22.1-q22.2.

引用

页码：25 / 34

页数：10

共 45 条

[11] STRUCTURE AND EVOLUTION OF THE HUMAN INVOLUCRIN GENE [J].