SEPARATION OF ENANTIOMERS AND DIASTEREOMERS OF 4-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE DERIVATIVES BY CAPILLARY ELECTROPHORESIS

被引：14

作者：

THUNECKE, F

HARTENSTEIN, H

SICKER, D

VOGT, C

机构：

[1] UNIV LEIPZIG,INST ANALYT CHEM,DEPT CHEM,D-04103 LEIPZIG,GERMANY

[2] UNIV LEIPZIG,INST ORGAN CHEM,DEPT CHEM,D-04103 LEIPZIG,GERMANY

来源：

CHROMATOGRAPHIA | 1994年 / 38卷 / 7-8期

关键词：

CAPILLARY ELECTROPHORESIS; 4-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONES; CYCLODEXTRINS; ENANTIOSEPARATION; SEPARATION OF DIASTEREOMERS;

D O I：

10.1007/BF02269838

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A high performance capillary electrophoresis (HPCE) procedure for the enantioseparation of the methyl acetals 3 and 4 of the natural products DIBOA 1 and DIMBOA 2, respectively, has been developed using berate buffers (pH 9-10 range), cyclodextrins as chiral additives and addition of up to 20 % methanol. A mixture of GDIBOA 5 and GDIMBOA 6 of natural origin was also clearly separated. HPCE proved to be superior to HPLC by the first separation of GDIBOA 5 and three of its diastereomers resulting from a synthetic approach to this acetalglucoside.

引用

页码：470 / 474

页数：5

共 18 条

[1] ANALOGS OF THE CYCLIC HYDROXAMIC ACID 2,4-DIHYDROXY-7-METHOXY-2H-1,4-BENZOXAZIN-3-ONE - DECOMPOSITION TO BENZOXAZOLINONES AND REACTION WITH BETA-MERCAPTOETHANOL [J].