ENANTIOMERIC SEPARATION OF CLOSE ANALOGS TO NATURALLY-OCCURRING 1,4-BENZOXAZIN-3-ONES BY LIQUID-CHROMATOGRAPHY USING BETA-CYCLODEXTRIN-MODIFIED STATIONARY PHASE

被引：12

作者：

LIPPMANN, T ^{[1
]}

HARTENSTEIN, H ^{[1
]}

SICKER, D ^{[1
]}

机构：

[1] UNIV LEIPZIG,INST ORGAN CHEM,TALSTR 35,O-7010 LEIPZIG,GERMANY

来源：

CHROMATOGRAPHIA | 1993年 / 35卷 / 5-6期

关键词：

COLUMN LIQUID CHROMATOGRAPHY; 1,4-BENZOXAZIN-3-ONES; CYCLIC HYDROXAMIC ACIDS; BETA-CYCLODEXTRIN MODIFIED SILICA GEL; ENANTIOMER SEPARATION;

D O I：

10.1007/BF02277514

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A liquid chromatographic procedure on a 5 mum LiChroCART column using chemically bonded beta-cyclodextrin (ChiraDex) as chiral selector was developed for the enantiomeric separation of four 2H-1,4-benzoxazin-3(4H)-ones which are close analogs of the cyclic hydroxamic acids 2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one (DIBOA) and 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3 (4H)-one (DIMBOA) naturally occurring in Gramineae species.

引用

页码：302 / 304

页数：3

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