THE DXS423E GENE IN XP11.21 ESCAPES X-CHROMOSOME INACTIVATION

被引：40

作者：

BROWN, CJ

MILLER, AP

CARREL, L

RUPERT, JL

DAVIES, KE

WILLARD, HF

机构：

[1] CASE WESTERN RESERVE UNIV,SCH MED,DEPT GENET,CLEVELAND,OH 44106

[2] CASE WESTERN RESERVE UNIV,SCH MED,CTR HUMAN GENET,CLEVELAND,OH 44106

[3] UNIV CLEVELAND HOSP,CLEVELAND,OH 44106

[4] STANFORD UNIV,DEPT GENET,STANFORD,CA 94305

[5] JOHN RADCLIFFE HOSP,INST MOLEC MED,MOLEC GENET GRP,OXFORD OX3 9DU,ENGLAND

来源：

HUMAN MOLECULAR GENETICS | 1995年 / 4卷 / 02期

关键词：

D O I：

10.1093/hmg/4.2.251

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The DXS423E gene has been localized to Xp11.21 and is expressed in somatic cell hybrids retaining either the human active or inactive X chromosome, demonstrating that DXS423E escapes X chromosome inactivation. The XE169 (DXS1272E or SMCX) gene that escapes X chromosome inactivation is also located in Xp11.21-11.22 and maps within the same YAC as DXS423E. Thus the DXS423E and XE169 genes define a new region in the proximal short arm of the X chromosome that is not subject to X chromosome inactivation, supporting a regional basis for escape from inactivation.

引用

页码：251 / 255

页数：5

共 33 条

[1] AGUINIK AI, 1994, HUM MOL GENET, V3, P873
[2] AGUINIK AI, 1994, HUM MOL GENET, V3, P879
[3] [Anonymous], [No title captured]
[4] BROWN CJ, 1989, AM J HUM GENET, V45, P592
[5] X-CHROMOSOME INACTIVATION OF THE HUMAN TIMP GENE
BROWN, CJ
FLENNIKEN, AM
WILLIAMS, BRG
WILLARD, HF
[J]. NUCLEIC ACIDS RESEARCH, 1990, 18 (14) : 4191 - 4195
[6] DAHL H, 1990, GENOMICS, V8, P8225
[7] THE PSEUDOAUTOSOMAL BOUNDARY IN MAN IS DEFINED BY AN ALU REPEAT SEQUENCE INSERTED ON THE Y-CHROMOSOME
ELLIS, NA
GOODFELLOW, PJ
PYM, B
SMITH, M
PALMER, M
FRISCHAUF, AM
GOODFELLOW, PN
[J]. NATURE, 1989, 337 (6202) : 81 - 84
[8] DIRECTED ISOLATION OF HUMAN GENES THAT ESCAPE X-INACTIVATION
ELLISON, J
PASSAGE, M
YU, LC
YEN, P
MOHANDAS, TK
SHAPIRO, L
[J]. SOMATIC CELL AND MOLECULAR GENETICS, 1992, 18 (03) : 259 - 268
[9] A GENE DELETED IN KALLMANNS SYNDROME SHARES HOMOLOGY WITH NEURAL CELL-ADHESION AND AXONAL PATH-FINDING MOLECULES
FRANCO, B
GUIOLI, S
PRAGLIOLA, A
INCERTI, B
BARDONI, B
TONLORENZI, R
CARROZZO, R
MAESTRINI, E
PIERETTI, M
TAILLONMILLER, P
BROWN, CJ
WILLARD, HF
LAWRENCE, C
PERSICO, MG
CAMERINO, G
BALLABIO, A
[J]. NATURE, 1991, 353 (6344) : 529 - 536
[10] GOODFELLOW P, 1984, AM J HUM GENET, V36, P777

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