THE DXS423E GENE IN XP11.21 ESCAPES X-CHROMOSOME INACTIVATION

被引：40

作者：

BROWN, CJ

MILLER, AP

CARREL, L

RUPERT, JL

DAVIES, KE

WILLARD, HF

机构：

[1] CASE WESTERN RESERVE UNIV,SCH MED,DEPT GENET,CLEVELAND,OH 44106

[2] CASE WESTERN RESERVE UNIV,SCH MED,CTR HUMAN GENET,CLEVELAND,OH 44106

[3] UNIV CLEVELAND HOSP,CLEVELAND,OH 44106

[4] STANFORD UNIV,DEPT GENET,STANFORD,CA 94305

[5] JOHN RADCLIFFE HOSP,INST MOLEC MED,MOLEC GENET GRP,OXFORD OX3 9DU,ENGLAND

来源：

HUMAN MOLECULAR GENETICS | 1995年 / 4卷 / 02期

关键词：

D O I：

10.1093/hmg/4.2.251

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The DXS423E gene has been localized to Xp11.21 and is expressed in somatic cell hybrids retaining either the human active or inactive X chromosome, demonstrating that DXS423E escapes X chromosome inactivation. The XE169 (DXS1272E or SMCX) gene that escapes X chromosome inactivation is also located in Xp11.21-11.22 and maps within the same YAC as DXS423E. Thus the DXS423E and XE169 genes define a new region in the proximal short arm of the X chromosome that is not subject to X chromosome inactivation, supporting a regional basis for escape from inactivation.

引用

页码：251 / 255

页数：5

共 33 条

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