ALTERATION OF DELTA-6 DESATURASE BY VITAMIN-E IN RAT-BRAIN AND LIVER

被引：24

作者：

DESPRET, S ^{[1
]}

DINH, L ^{[1
]}

CLEMENT, M ^{[1
]}

BOURRE, JM ^{[1
]}

机构：

[1] HOP FERNAND WIDAL,INSERM,U26,200 RUE FG ST DENIS,F-75475 PARIS 10,FRANCE

来源：

NEUROSCIENCE LETTERS | 1992年 / 145卷 / 01期

关键词：

DELTA-6; DESATURASE; VITAMIN-E; LIVER; BRAIN; RAT;

D O I：

10.1016/0304-3940(92)90193-B

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

DELTA-6 Desaturase, measured at substrate saturation using linoleic acid, was found to be increased by more than two-fold when the content of vitamin E in brain microsomal membrane suspension was increased (up to 7.5 mug/mg membrane protein, i.e. 100 mug/g tissue from which microsomes were prepared). In contrast, this activity was reduced by 25% in the liver. This raises the question of the multiple role of vitamin E in membranes, the control of membrane polyunsaturated fatty acids through synthesis, and their protection against peroxidation.

引用

页码：19 / 22

页数：4

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