ALTERATION OF DELTA-6 DESATURASE BY VITAMIN-E IN RAT-BRAIN AND LIVER

被引:24
作者
DESPRET, S [1 ]
DINH, L [1 ]
CLEMENT, M [1 ]
BOURRE, JM [1 ]
机构
[1] HOP FERNAND WIDAL,INSERM,U26,200 RUE FG ST DENIS,F-75475 PARIS 10,FRANCE
关键词
DELTA-6; DESATURASE; VITAMIN-E; LIVER; BRAIN; RAT;
D O I
10.1016/0304-3940(92)90193-B
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
DELTA-6 Desaturase, measured at substrate saturation using linoleic acid, was found to be increased by more than two-fold when the content of vitamin E in brain microsomal membrane suspension was increased (up to 7.5 mug/mg membrane protein, i.e. 100 mug/g tissue from which microsomes were prepared). In contrast, this activity was reduced by 25% in the liver. This raises the question of the multiple role of vitamin E in membranes, the control of membrane polyunsaturated fatty acids through synthesis, and their protection against peroxidation.
引用
收藏
页码:19 / 22
页数:4
相关论文
共 36 条
[1]   EFFECT OF DIETARY POLY-UNSATURATED FATTY-ACIDS ON TISSUE VITAMIN-E STATUS [J].
BIERI, JG ;
THORP, SL ;
TOLLIVER, TJ .
JOURNAL OF NUTRITION, 1978, 108 (03) :392-398
[2]   KINETICS OF TISSUE ALPHA-TOCOPHEROL DEPLETION AND REPLETION [J].
BIERI, JG .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1972, 203 (DEC18) :181-191
[3]   ALTERATION OF THE ALPHA-TOCOPHEROL CONTENT IN THE BRAIN AND PERIPHERAL NERVOUS-TISSUE OF DYSMYELINATING MUTANTS [J].
BOURRE, JM ;
CLEMENT, M ;
CHAUDIERE, J .
NEUROCHEMICAL PATHOLOGY, 1987, 7 (02) :91-97
[4]   KINETICS OF RAT PERIPHERAL-NERVE, FOREBRAIN AND CEREBELLUM ALPHA-TOCOPHEROL DEPLETION - COMPARISON WITH DIFFERENT ORGANS [J].
BOURRE, JM ;
CLEMENT, M .
JOURNAL OF NUTRITION, 1991, 121 (08) :1204-1207
[5]   DELTA-6 DESATURASE IN BRAIN AND LIVER DURING DEVELOPMENT AND AGING [J].
BOURRE, JM ;
PICIOTTI, M ;
DUMONT, O .
LIPIDS, 1990, 25 (06) :354-356
[6]   EFFECT OF UNSATURATED-ACIDS ON MEMBRANE-STRUCTURE AND ENZYME-KINETICS [J].
BRENNER, RR .
PROGRESS IN LIPID RESEARCH, 1984, 23 (02) :69-96
[7]   ALPHA-TOCOPHEROL (VITAMIN-E) CONTENT OF LUNG, LIVER, AND BLOOD IN THE NEWBORN RAT AND HUMAN INFANT - INFLUENCE OF HYPEROXIA [J].
BUCHER, JR ;
ROBERTS, RJ .
JOURNAL OF PEDIATRICS, 1981, 98 (05) :806-811
[8]  
BURTON GW, 1990, ANNU REV NUTR, V10, P357, DOI 10.1146/annurev.nutr.10.1.357
[9]   THE RELATIONSHIP BETWEEN ALPHA-TOCOPHEROL AND PHOSPHOLIPID FATTY-ACIDS IN RAT-LIVER SUBCELLULAR MEMBRANE-FRACTIONS [J].
BUTTRISS, JL ;
DIPLOCK, AT .
BIOCHIMICA ET BIOPHYSICA ACTA, 1988, 962 (01) :81-90
[10]   THE ALPHA-TOCOPHEROL AND PHOSPHOLIPID FATTY-ACID CONTENT OF RAT-LIVER SUBCELLULAR MEMBRANES IN VITAMIN-E AND SELENIUM DEFICIENCY [J].
BUTTRISS, JL ;
DIPLOCK, AT .
BIOCHIMICA ET BIOPHYSICA ACTA, 1988, 963 (01) :61-69