RETINOIDS AS TERATOGENS

被引：110

作者：

SOPRANO, DR

SOPRANO, KJ

机构：

[1] TEMPLE UNIV, SCH MED, FELS INST CANC RES & MOLEC BIOL, PHILADELPHIA, PA 19140 USA

[2] TEMPLE UNIV, SCH MED, DEPT MICROBIOL & IMMUNOL, PHILADELPHIA, PA 19140 USA

来源：

ANNUAL REVIEW OF NUTRITION | 1995年 / 15卷

关键词：

RETINOL; RETINOIC ACID; TERATOLOGY; DYSMORPHOGENESIS; RAR;

D O I：

10.1146/annurev.nu.15.070195.000551

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Vitamin A is a necessary nutrient in the diet. However, excessive doses of retinoids by pregnant women result in teratogenesis. In this chapter, we initially discuss the occurrence and characteristics of fetal malformations associated with maternal ingestion of natural and synthetic retinoids in both experimental animals and humans. We then turn to an examination of the pharmacology of teratogenic retinoids, focusing on structure-function relationships and pharmacokinetics. Finally, we review the current literature on the molecular mechanism of action of teratogenic doses of retinoids and the role of the retinoic acid receptors and other target genes in this process.

引用

页码：111 / 132

页数：22

共 117 条

[41]

IZPISUABELMONTE J, 1991, SEMIN DEV BIOL, V2, P385

[42] TERATOGENESIS BY RETINOIC ACID ANALOGS POSITIVELY CORRELATES WITH ELEVATION OF RETINOIC ACID RECEPTOR-BETA-2 MESSENGER-RNA LEVELS IN TREATED EMBRYOS [J].