A MUTATED INTRON SEQUENCE CODES FOR AN ANTIGENIC PEPTIDE RECOGNIZED BY CYTOLYTIC T-LYMPHOCYTES ON A HUMAN-MELANOMA

被引：356

作者：

COULIE, PG ^{[1
]}

LEHMANN, F ^{[1
]}

LETHE, B ^{[1
]}

HERMAN, J ^{[1
]}

LURQUIN, C ^{[1
]}

ANDRAWISS, M ^{[1
]}

BOON, T ^{[1
]}

机构：

[1] UNIV CATHOLIQUE LOUVAIN,CELLULAR GENET UNIT,B-1200 BRUSSELS,BELGIUM

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 17期

关键词：

D O I：

10.1073/pnas.92.17.7976

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have identified an antigen recognized on a human melanoma by autologous cytolytic T lymphocytes. It is encoded by a gene that is expressed in many normal tissues. Remarkably, the sequence coding for the antigenic peptide is located across an exon-intron junction. A point mutation is present in the intron that generates an amino acid change that is essential for the recognition of the peptide by the anti-tumor cytotoxic T lymphocytes. This observation suggests that the T-cell-mediated surveillance of the integrity of the genome may extend to some intronic regions.

引用

页码：7976 / 7980

页数：5

共 35 条

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