TGF-BETA-1 EXPRESSION IS INITIATED IN ADULT AUDITORY NEURONS BY SECTIONING OF THE AUDITORY-NERVE

被引：30

作者：

LEFEBVRE, PP

MARTIN, D

STAECKER, H

WEBER, T

MOONEN, G

VANDEWATER, TR

机构：

[1] STATE UNIV LIEGE,DEPT OTORHINOLARYNGOL & AUDIOPHONOL,B-4000 LIEGE,BELGIUM

[2] STATE UNIV LIEGE,DEPT NEUROSURG,B-4000 LIEGE,BELGIUM

[3] YESHIVA UNIV ALBERT EINSTEIN COLL MED,INST COMMUN DISORDERS,DEPT OTOLARYNGOL,BRONX,NY 10461

[4] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT NEUROSCI,BRONX,NY 10461

来源：

NEUROREPORT | 1992年 / 3卷 / 04期

关键词：

AUDITORY NEURONS; TGF-BETA-1; AXOTOMY;

D O I：

10.1097/00001756-199204000-00001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

NEURONOTROPHIC factors (e.g. basic fibroblast growth factor, bFGF and nerve growth factor, NGF) have been demonstrated to respectively promote survival and neuritogenesis in cultures of dissociated adult rat spiral ganglia. Transforming growth factor beta (TGF-beta(1)) has been shown to modulate the response of cultured auditory neurons to bFGF through the induction of high affinity receptors for bFGF in the neurons. In this study, we show that TGF-beta(1) is expressed in situ by adult auditory neurons in response to traumatic injury (i.e. transection of the eighth cranial nerve). Based on these in vivo results and on the results from our previous in vitro studies, we propose that TFG-beta(1) acts as an early autocrine signal involved in the response to injury by neurons of the peripheral auditor system.

引用

页码：295 / 298

页数：4

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