ENZYMATIC RESOLUTION OF (R,S)-2-(4-HYDROXYPHENOXY) PROPIONIC-ACID

被引：34

作者：

BARTON, MJ ^{[1
]}

HAMMAN, JP ^{[1
]}

FICHTER, KC ^{[1
]}

CALTON, GJ ^{[1
]}

机构：

[1] RHONE POULENC RES CTR INC,SAVAGE,MD

来源：

ENZYME AND MICROBIAL TECHNOLOGY | 1990年 / 12卷 / 08期

关键词：

(R; S)-2-(4-hydroxyphenoxy)propionic acid; Enzymatic resolution;

D O I：

10.1016/0141-0229(90)90130-I

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The enzymatic resolution of (R,S)-2-(4-hydroxyphenoxy)propionic acid was accomplished by treatment of the methyl ester in an aqueous/organic mixture with a number of commercially available Candida rugosa lipase preparations. With toluene as the organic phase, an enantiomeric excess of 88% to >99% could be obtained at 31% to 38% hydrolysis of the methyl ester. © 1990.

引用

页码：577 / 583

页数：7

共 17 条

[11] RESOLUTION OF RACEMIC MIXTURES VIA LIPASE CATALYSIS IN ORGANIC-SOLVENTS [J].