SYNTHESIS OF SUBSTITUTED 2-AMINOPYRROLE ANALOGS OF LIDOCAINE-II

被引：11

作者：

JOHNSON, RW ^{[1
]}

KEENAN, TH ^{[1
]}

KOSH, JW ^{[1
]}

SOWELL, JW ^{[1
]}

机构：

[1] UNIV S CAROLINA,DEPT PHARM,COLUMBIA,SC 29208

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 08期

关键词：

Antiarrhythmic agents—lidocaine analogs; synthesis; structure‐activity relationships; Lidocaine analogs—synthesis of 2‐diethylaminoacetamido‐3‐carbamyl‐4‐methylpyrroles; local anesthetic activity; antiarrhythmic activity; Local anesthetic agents—lidocaine analogs; structure activity relationships; Structure‐activity relationships—lidocaine analogs;

D O I：

10.1002/jps.2600680810

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and local anesthetic and antiarrhythmic properties of eight substituted 2‐diethylaminoacetamido‐3‐carbamyl‐4‐methylpyrroles are described. Three compounds showed significant local anesthetic activity by the guinea pig wheal test, and four showed antiarrhythmic activity against chloroform‐induced ventricular arrhythmias in mice. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：955 / 958

页数：4

共 6 条

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[2]

Gewald K., 1961, Z CHEM, V1, P349

[3] SYNTHESIS OF SUBSTITUTED 2-AMINOPYRROLE ANALOGS OF LIDOCAINE .1. [J].

JOHNSON, RW ;

KEENAN, TH ;

KOSH, JW ;

SOWELL, JW .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1979, 68 (03) :317-320

[4] SYNTHESIS OF SUBSTITUTED 2-AMINO-3-CYANO-4-METHYLPYRROLES [J].

JOHNSON, RW ;

MATTSON, RJ ;

SOWELL, JW .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1977, 14 (03) :383-385

[5]

LAWSON JW, 1968, J PHARMACOL EXP THER, V160, P22

[6]

SHVEDOV VI, 1975, KHIM GETEROTSIKL SOE, V9, P1219

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