SEX-RELATED DIFFERENCES AND THYROID-HORMONE REGULATION OF VASOACTIVE-INTESTINAL-PEPTIDE GENE-EXPRESSION IN THE RAT-BRAIN AND PITUITARY

被引：25

作者：

LAM, KSL

SRIVASTAVA, G

机构：

[1] Departments of Medicine and Pathology, University of Hong Kong, Queen Mary Hospital, Hong Kong

来源：

BRAIN RESEARCH | 1990年 / 526卷 / 01期

关键词：

Anterior pituitary; Brain; Gene expression; Rat; Sexual dimorphism; Thyroid hormone; Vasoactive intestinal peptide;

D O I：

10.1016/0006-8993(90)90259-E

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To determine the effects of hypothyroidism and sexual dimorphism on the gene expression of vasoactive intestinal peptide (VIP) in the rat brain, VIP mRNA levels were measured in the cerebral cortex, hypothalamus and anterior pituitary of control and hypothyroid (thionamide-treated) rats. A tissue-specific increase in VIP mRNA level was observed in the hypothyroid pituitary. In addition, higher levels of VIP mRNA were found in the pituitaries of male rats suggesting a sex-related difference in VIP gene expression. Similar differences were not observed in the cortex or hypothalamus. © 1990.

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页码：135 / 137

页数：3

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