CHARACTERIZATION OF TAXOL IN METHYLENE-CHLORIDE BY NMR-SPECTROSCOPY

被引：52

作者：

FALZONE, CJ

BENESI, AJ

LECOMTE, JTJ

机构：

[1] Department of Chemistry, The Pennsylvania State University University Park

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 09期

关键词：

TAXOL; NMR;

D O I：

10.1016/S0040-4039(00)91887-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The H-1 and C-13 NMR spectra of taxol in methylene chloride were analyzed using two-dimensional methods. C-13 chemical shift assignments were made based on inverse-detected two-dimensional NMR experiments and are reported. The NOESY data collected in this solvent suggest that the structure in solution is similar to the X-ray structure of the taxol analogue taxotere.

引用

页码：1169 / 1172

页数：4