SYNTHETIC ANGUCYCLINS .2. FIRST TOTAL SYNTHESIS OF (+/-)-RABELOMYCIN

被引：62

作者：

KROHN, K

KHANBABAEE, K

机构：

[1] Fachbereich Chemie Und Chemietechnik, Universität-Gesamthochschule Paderborn, D-33098

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1994年 / 33卷 / 01期

关键词：

D O I：

10.1002/anie.199400991

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

To hold the position for a labile hydroxyl group and to direct a regioselective deprotonation, the Si2Me5 group is introduced in the diene component 3, from which the antibiotic rac‐rabelomycin (4) is accessible through cycloaddition and subsequent photooxygenation. This procedure emphasizes the usefulness of the pentamethylsilyllithium 2, readily prepared from disilane 1, for the synthesis of tertiary alcohols. (Figure Presented.) Copyright © 1994 by VCH Verlagsgesellschaft mbH, Germany

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页码：99 / 100

页数：2

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