SYNTHESIS AND BIOLOGICAL-ACTIVITY OF IODINATED AND PHOTOSENSITIVE DERIVATIVES OF TETRABENAZINE

被引：5

作者：

ARANDA, G

BEAUCOURT, JP

PONCHANT, M

ISAMBERT, MF

HENRY, JP

机构：

[1] INST BIOL PHYS CHIM,NEUROBIOL PHYS CHIM LAB,F-75005 PARIS,FRANCE

[2] CENS,SERV MOLEC MARQUEES,F-91191 GIF SUR YVETTE,FRANCE

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1990年 / 25卷 / 04期

关键词：

catecholamines carrier; iodinated ligand; neuroleptic tetrabenazine; photoaffinity labelling;

D O I：

10.1016/0223-5234(90)90121-I

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of a photosensitive iodinated derivative of tetrabenazine, which should be able to lead to the identification of the vesicular catecholamine transporter of adrenal medulla by photoaffinity, is described in detail. The biological activity of this iodinated ligand was found to be significantly lower than that of non iodinated ligands. © 1990.

引用

页码：369 / 374

页数：6