CLINICAL IMPLICATIONS OF SLOW SULFOXIDATION OF THIORIDAZINE IN A POOR METABOLIZER OF THE DEBRISOQUINE TYPE

被引：65

作者：

MEYER, JW

WOGGON, B

BAUMANN, P

MEYER, UA

机构：

[1] UNIV ZURICH,HOSP PSYCHIAT,RES DEPT,CH-8006 ZURICH,SWITZERLAND

[2] UNIV LAUSANNE,HOSP PSYCHIAT,RES DEPT,PRILLY,SWITZERLAND

[3] UNIV BASEL,BIOCTR,CH-4056 BASEL,SWITZERLAND

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1990年 / 39卷 / 06期

关键词：

D O I：

10.1007/BF00316110

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：613 / 614

页数：2

共 10 条

[1] GC AND GC-MS PROCEDURES FOR SIMULTANEOUS PHENOTYPING WITH DEXTROMETHORPHAN AND MEPHENYTOIN [J].

BAUMANN, P ;

JONZIERPEREY, M .

CLINICA CHIMICA ACTA, 1988, 171 (2-3) :211-222

[2] DEFECTIVE N-OXIDATION OF SPARTEINE IN MAN - NEW PHARMACOGENETIC DEFECT [J].

EICHELBAUM, M ;

SPANNBRUCKER, N ;

STEINCKE, B ;

DENGLER, HJ .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1979, 16 (03) :183-187

[3]

Evans D A, 1986, Prog Clin Biol Res, V214, P491

[4]

GONZALES FJ, 1988, NATURE, V33, P442

[5] SIMULTANEOUS DETERMINATION OF THIORIDAZINE AND ITS OXIDIZED AND N-DEMETHYLATED METABOLITES USING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY ON RADIALLY COMPRESSED SILICA [J].

KILTS, CD ;

PATRICK, KS ;

BREESE, GR ;

MAILMAN, RB .

JOURNAL OF CHROMATOGRAPHY, 1982, 231 (02) :377-391

[6]

MAGHOUB A, 1977, LANCET, V2, P584

[7] THE MOLECULAR MECHANISMS OF 2 COMMON POLYMORPHISMS OF DRUG OXIDATION - EVIDENCE FOR FUNCTIONAL-CHANGES IN CYTOCHROME-P-450 ISOZYMES CATALYZING BUFURALOL AND MEPHENYTOIN OXIDATION [J].

MEYER, UA ;

GUT, J ;

KRONBACH, T ;

SKODA, C ;

MEIER, UT ;

CATIN, T ;

DAYER, P .

XENOBIOTICA, 1986, 16 (05) :449-464

[8] POLYMORPHIC DEXTROMETHORPHAN METABOLISM - CO-SEGREGATION OF OXIDATIVE O-DEMETHYLATION WITH DEBRISOQUIN HYDROXYLATION [J].

SCHMID, B ;

BIRCHER, J ;

PREISIG, R ;

KUPFER, A .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1985, 38 (06) :618-624

[9] 2 MUTANT ALLELES OF THE HUMAN CYTOCHROME-P-450DB1 GENE (P450C2D1) ASSOCIATED WITH GENETICALLY DEFICIENT METABOLISM OF DEBRISOQUINE AND OTHER DRUGS [J].

SKODA, RC ;

GONZALEZ, FJ ;

DEMIERRE, A ;

MEYER, UA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (14) :5240-5243

[10]

VONBAHR C, 1985, CLIN PHARM PSYCHIATR

← 1 →