THE MOLECULAR MECHANISMS OF 2 COMMON POLYMORPHISMS OF DRUG OXIDATION - EVIDENCE FOR FUNCTIONAL-CHANGES IN CYTOCHROME-P-450 ISOZYMES CATALYZING BUFURALOL AND MEPHENYTOIN OXIDATION

被引：146

作者：

MEYER, UA ^{[1
]}

GUT, J ^{[1
]}

KRONBACH, T ^{[1
]}

SKODA, C ^{[1
]}

MEIER, UT ^{[1
]}

CATIN, T ^{[1
]}

DAYER, P ^{[1
]}

机构：

[1] UNIV GENEVA HOSP,CLIN PHARMACOL UNIT,CH-1211 GENEVA 4,SWITZERLAND

来源：

XENOBIOTICA | 1986年 / 16卷 / 05期

关键词：

D O I：

10.3109/00498258609050251

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：449 / 464

页数：16

共 29 条

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[5] CHARACTERIZATION OF A COMMON GENETIC-DEFECT OF CYTOCHROME-P-450 FUNCTION (DEBRISOQUINE-SPARTEINE TYPE POLYMORPHISM) - INCREASED MICHAELIS CONSTANT (KM) AND LOSS OF STEREOSELECTIVITY OF BUFURALOL 1'-HYDROXYLATION IN POOR METABOLIZERS
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[6] STERIC CONFIGURATION AND POLYMORPHIC OXIDATION OF LIPOPHILIC BETA-ADRENOCEPTOR BLOCKING-AGENTS - INVIVO INVITRO CORRELATIONS
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[7] THE GENETIC-CONTROL OF BUFURALOL METABOLISM IN MAN
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[8] DAYER P, 1985, EXPERIENTIA, V41, P46
[9] CHARACTERIZATION OF A HUMAN-LIVER CYTOCHROME-P-450 INVOLVED IN THE OXIDATION OF DEBRISOQUINE AND OTHER DRUGS BY USING ANTIBODIES RAISED TO THE ANALOGOUS RAT ENZYME
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[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (23): : 7348 - 7352
[10] INTER-ETHNIC DIFFERENCE IN SPARTEINE OXIDATION AMONG GHANAIANS AND GERMANS
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[J]. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1985, 28 (01) : 79 - 83

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