NATURAL-PRODUCTS WHICH INTERACT WITH TUBULIN IN THE VINCA DOMAIN - MAYTANSINE, RHIZOXIN, PHOMOPSIN-A, DOLASTATIN-10 AND DOLASTATIN-15 AND HALICHONDRIN-B

被引：163

作者：

HAMEL, E

机构：

来源：

PHARMACOLOGY & THERAPEUTICS | 1992年 / 55卷 / 01期

关键词：

D O I：

10.1016/0163-7258(92)90028-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This paper summarizes published data on the interactions of tubulin with antimitotic compounds that inhibit the binding of vinca alkaloids to the protein. These are all relatively complex natural products isolated from higher plants, fungi and marine invertebrate animals. These agents are maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B and their congeners. Effects on tubulin polymerization, ligand binding interactions and structure-activity relationships are emphasized.

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页码：31 / 51

页数：21

相关论文

共 102 条

[1] TOTAL SYNTHESIS OF HALICHONDRIN-B AND NORHALICHONDRIN-B [J].

AICHER, TD ;

BUSZEK, KR ;

FANG, FG ;

FORSYTH, CJ ;

JUNG, SH ;

KISHI, Y ;

MATELICH, MC ;

SCOLA, PM ;

SPERO, DM ;

YOON, SK .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (08) :3162-3164

[2] CHARACTERIZATION OF POSTTRANSLATIONAL MODIFICATIONS IN NEURON-SPECIFIC CLASS-III BETA-TUBULIN BY MASS-SPECTROMETRY [J].

ALEXANDER, JE ;

HUNT, DF ;

LEE, MK ;

SHABANOWITZ, J ;

MICHEL, H ;

BERLIN, SC ;

MACDONALD, TL ;

SUNDBERG, RJ ;

REBHUN, LI ;

FRANKFURTER, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (11) :4685-4689

[3] ROLE OF GTP IN ASSEMBLY OF MICROTUBULES [J].

ARAI, T ;

KAZIRO, Y .

JOURNAL OF BIOCHEMISTRY, 1977, 82 (04) :1063-1071

[4] INCORPORATION OF L-TYROSINE, L-PHENYLALANINE AND L-3,4-DIHYDROXYPHENYLALANINE AS SINGLE UNITS INTO RAT-BRAIN TUBULIN [J].

ARCE, CA ;

RODRIGUEZ, JA ;

BARRA, HS ;

CAPUTTO, R .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1975, 59 (01) :145-149

[5] ISOLATION, CHEMICAL CHARACTERIZATION AND STRUCTURE OF ANSAMITOCIN, A NEW ANTI-TUMOR ANSAMYCIN ANTIBIOTIC [J].

ASAI, M ;

MIZUTA, E ;

IZAWA, M ;

HAIBARA, K ;

KISHI, T .

TETRAHEDRON, 1979, 35 (09) :1079-1085

[6] STRUCTURE ACTIVITY STUDIES WITH CHIRAL ISOMERS AND WITH SEGMENTS OF THE ANTIMITOTIC MARINE PEPTIDE DOLASTATIN-10 [J].

BAI, R ;

PETTIT, GR ;

HAMEL, E .

BIOCHEMICAL PHARMACOLOGY, 1990, 40 (08) :1859-1864

[7]

BAI R, 1991, J BIOL CHEM, V266, P15882

[8]

BAI R, 1990, J BIOL CHEM, V265, P17141

[9] DOLASTATIN-10, A POWERFUL CYTOSTATIC PEPTIDE DERIVED FROM A MARINE ANIMAL - INHIBITION OF TUBULIN POLYMERIZATION MEDIATED THROUGH THE VINCA ALKALOID BINDING DOMAIN [J].

BAI, R ;

PETTIT, GR ;

HAMEL, E .

BIOCHEMICAL PHARMACOLOGY, 1990, 39 (12) :1941-1949

[10] DOLASTATIN-15, A POTENT ANTIMITOTIC DEPSIPEPTIDE DERIVED FROM DOLABELLA-AURICULARIA - INTERACTION WITH TUBULIN AND EFFECTS ON CELLULAR MICROTUBULES [J].

BAI, R ;

FRIEDMAN, SJ ;

PETTIT, GR ;

HAMEL, E .

BIOCHEMICAL PHARMACOLOGY, 1992, 43 (12) :2637-2645

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