NATURAL-PRODUCTS WHICH INTERACT WITH TUBULIN IN THE VINCA DOMAIN - MAYTANSINE, RHIZOXIN, PHOMOPSIN-A, DOLASTATIN-10 AND DOLASTATIN-15 AND HALICHONDRIN-B

被引：163

作者：

HAMEL, E

机构：

来源：

PHARMACOLOGY & THERAPEUTICS | 1992年 / 55卷 / 01期

关键词：

D O I：

10.1016/0163-7258(92)90028-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This paper summarizes published data on the interactions of tubulin with antimitotic compounds that inhibit the binding of vinca alkaloids to the protein. These are all relatively complex natural products isolated from higher plants, fungi and marine invertebrate animals. These agents are maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B and their congeners. Effects on tubulin polymerization, ligand binding interactions and structure-activity relationships are emphasized.

引用

收藏

页码：31 / 51

页数：21

相关论文

共 102 条

[31]

IBARAKI T, 1973, Annals of the Phytopathological Society of Japan, V39, P141

[32] STUDIES ON MACROCYCLIC LACTONE ANTIBIOTICS .8. ABSOLUTE STRUCTURES OF RHIZOXIN AND A RELATED COMPOUND [J].

IWASAKI, S ;

NAMIKOSHI, M ;

KOBAYASHI, H ;

FURUKAWA, J ;

OKUDA, S ;

ITAI, A ;

KASUYA, A ;

IITAKA, Y .

JOURNAL OF ANTIBIOTICS, 1986, 39 (03) :424-429

[33]

IWASAKI S, 1986, CHEM PHARM BULL, V34, P1387

[34] STUDIES ON MACROCYCLIC LACTONE ANTIBIOTICS .7. STRUCTURE OF A PHYTOTOXIN RHIZOXIN PRODUCED BY RHIZOPUS-CHINENSIS [J].

IWASAKI, S ;

KOBAYASHI, H ;

FURUKAWA, J ;

NAMIKOSHI, M ;

OKUDA, S ;

SATO, Z ;

MATSUDA, I ;

NODA, T .

JOURNAL OF ANTIBIOTICS, 1984, 37 (04) :354-362

[35] STUDIES ON MACROCYCLIC LACTONE ANTIBIOTICS .13. ANTITUBULIN ACTIVITY AND CYTOTOXICITY OF RHIZOXIN DERIVATIVES - SYNTHESIS OF A PHOTOAFFINITY DERIVATIVE [J].

KATO, Y ;

OGAWA, Y ;

IMADA, T ;

IWASAKI, S ;

SHIMAZAKI, N ;

KOBAYASHI, T ;

KOMAI, T .

JOURNAL OF ANTIBIOTICS, 1991, 44 (01) :66-75

[36]

KOBAYASH.T, 1974, J BIOCHEM-TOKYO, V76, P201, DOI 10.1093/oxfordjournals.jbchem.a130546

[37] STUDIES ON MACROCYCLIC LACTONE ANTIBIOTICS .10. BIOSYNTHESIS OF THE ANTIMITOTIC ANTITUMOR ANTIBIOTIC RHIZOXIN BY RHIZOPUS-CHINENSIS - ORIGINS OF THE CARBON-ATOMS [J].

KOBAYASHI, H ;

IWASAKI, S ;

YAMADA, E ;

OKUDA, S .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1986, (23) :1702-1703

[38] COMPLETE AMINO-ACID-SEQUENCE OF BETA-TUBULIN FROM PORCINE BRAIN [J].

KRAUHS, E ;

LITTLE, M ;

KEMPF, T ;

HOFERWARBINEK, R ;

ADE, W ;

PONSTINGL, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (07) :4156-4160

[39] TUMOR INHIBITORS .122. MAYTANSINOIDS - ISOLATION, STRUCTURAL ELUCIDATION, AND CHEMICAL INTERRELATION OF NOVEL ANSA MACROLIDES [J].

KUPCHAN, SM ;

KOMODA, Y ;

BRANFMAN, AR ;

SNEDEN, AT ;

COURT, WA ;

THOMAS, GJ ;

HINTZ, HPJ ;

SMITH, RM ;

KARIM, A ;

HOWIE, GA ;

VERMA, AK ;

NAGAO, Y ;

DAILEY, RG ;

ZIMMERLY, VA ;

SUMNER, WC .

JOURNAL OF ORGANIC CHEMISTRY, 1977, 42 (14) :2349-2357

[40] NOVEL MAYTANSINOIDS - STRUCTURAL INTERRELATIONS AND REQUIREMENTS FOR ANTILEUKEMIC ACTIVITY [J].

KUPCHAN, SM ;

KOMODA, Y ;

BRANFMAN, AR ;

DAILEY, RG ;

ZIMMERLY, VA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1974, 96 (11) :3706-3708

← 1 2 3 4 5 6 7 8 9 10 →