5-HT1A RECEPTOR AGONISTS REDUCE ETHANOL-INDUCED LOCOMOTOR-ACTIVITY IN MICE

被引：24

作者：

BLOMQVIST, O

SODERPALM, B

ENGEL, JA

机构：

[1] Department of Pharmacology, University of Göteborg, S-413 90 Göteborg

来源：

ALCOHOL | 1994年 / 11卷 / 02期

关键词：

BUSPIRONE; ETHANOL; IPSAPIRONE; LOCOMOTOR ACTIVITY; MICE; 8-OH-DPAT;

D O I：

10.1016/0741-8329(94)90057-4

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Animal studies as well as clinical studies have suggested that the brain 5-HT system is important for the regulation of voluntary ethanol intake and preference. Previous studies have suggested that 5-HT1A receptor agonists may reduce ethanol preference in rats. In the present study on mice, the 5-HT1A receptor agonists (8-OH-DPAT), ipsapirone, and buspirone all antagonized the locomotor activity (LMA) stimulatory effect of ethanol (2.5 g/kg). The present results provide further support for the notion that the LMA-increasing effect of ethanol may be homologous to its reinforcing properties and that 5-HT1A receptor agonists may counteract these properties as well.

引用

页码：157 / 161

页数：5

共 34 条

[1] RESTORATION OF LOCOMOTOR ACTIVITY IN MICE BY LOW L-DOPA DOSES AFTER SUPPRESSION BY ALPHA-METHYLTYROSINE BUT NOT BY RESERPINE [J].