HYDROGEN-BONDING STRUCTURAL STUDY OF SOLID PEPTIDES AND POLYPEPTIDES CONTAINING A GLYCINE RESIDUE BY O-17 NMR-SPECTROSCOPY

被引：53

作者：

KUROKI, S

TAKAHASHI, A

ANDO, I

SHOJI, A

OZAKI, T

机构：

[1] TOKYO INST TECHNOL,DEPT POLYMER CHEM,MEGURO KU,TOKYO 152,JAPAN

[2] GUNMA UNIV,DEPT BIOL SCI,KIRYU,GUNMA 376,JAPAN

来源：

JOURNAL OF MOLECULAR STRUCTURE | 1994年 / 323卷

关键词：

D O I：

10.1016/0022-2860(94)07993-5

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Static O-17 NMR spectra of polyglycines I and II and glycylglycine peptides in the solid state were measured by the cross polarization technique. By computer simulations of these spectra, three NMR parameters (quadrupolar coupling constant (e2qQ/h), electric field gradient asymmetry parameter (eta(Q)), and chemical shift (delta)) were determined. From these results, it was found that as the hydrogen bond length decreased, the e2qQ/h value decreased. Furthermore, the principal values of the O-17 chemical shift tensor for both the peptides and polypeptides moved upfield with a decrease in the hydrogen bond length. From these experimental findings, it was clarified that O-17 NMR spectroscopy can provide a useful means of elucidating the hydrogen-bonding structure in solid peptides and polypeptides.

引用

页码：197 / 208

页数：12

共 27 条

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