TUMOR-INDUCED ALTERATIONS IN BRAIN NEUROTRANSMITTER AND PLASMA AMMONIA CONCENTRATIONS ARE NORMALIZED 24 HOURS AFTER TUMOR RESECTION

被引：12

作者：

CHANCE, WT ^{[1
]}

CAO, LQ ^{[1
]}

FISCHER, JE ^{[1
]}

机构：

[1] VET AFFAIRS MED CTR,CINCINNATI,OH 45267

来源：

LIFE SCIENCES | 1991年 / 48卷 / 05期

关键词：

D O I：

10.1016/0024-3205(91)90498-Z

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Tumor-induced anorexia was accompanied by significant elevations in plasma ammonia and lactate and by alteration of the plasma amino acid profile. The brains of anorectic tumor-bearing rats had increased levels of glutamine and most large neutral amino acids. Dopamine and serotonin metabolism were also increased in several brain regions of these rats. Resection of the tumor resulted in the normalization of most of these aberrations in blood and brain within 24 hours. These results demonstrate a rapid reversal of tumor-induced biochemical alterations shortly after tumor removal and suggest that these aberrations may be secondary to hyperammonemia.

引用

页码：425 / 432

页数：8

共 22 条

[1]

CARRASCOSA JM, 1984, CANCER RES, V44, P3831

[2] SEROTONIN DEPLETION BY 5,7-DIHYDROXYTRYPTAMINE OR PARA-CHLOROAMPHETAMINE DOES NOT AFFECT CANCER ANOREXIA [J].