SYNTHESIS OF INOSITOL PHOSPHOLIPIDS WITH THIOPHOSPHOESTER BONDS

被引：11

作者：

ALISI, MA

BRUFANI, M

FILOCAMO, L

GOSTOLI, G

MAIORANA, S

机构：

[1] UNIV ROME LA SAPIENZA,DIPARTIMENTO SCI BIOCHIM A ROSSI FANELLI,VIA APULI 9,I-00185 ROME,ITALY

[2] UNIV MILAN,DIPARTIMENTO CHIM ORGAN & IND,I-20133 MILAN,ITALY

[3] MEDIOLANUM FARMACEUT SPA,I-20143 MILAN,ITALY

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 50期

关键词：

D O I：

10.1016/0040-4039(93)88048-N

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of phosphatidylinositol (PI) analogues (+/-)1-O-(1-O-octadecanoyl-2-O-acetyl-rac-3-thioglycerylphosphoryl)-myo-inositol (7), (+/-)1-O-(1,2-di-O-octadecyl-rac-3-thiogly-cerylphosphoryl)-myo-inositol (14a), (+/-)1-O-(1,2-di-O-octyl-rac-3-thioglycerylphosphoryl)-myo-inositol (14b) and (+/-)1-O-(1-O-octadecyl-2-O-methyl-rac-3-thioglycerylphosphoryl)-myo-inositol (14c) designed to show a novel mode of PI-phospholipase C (PI-PLC) inhibition, is described.

引用

页码：7793 / 7796

页数：4

共 11 条

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[J]. TETRAHEDRON LETTERS, 1992, 33 (27) : 3891 - 3894
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