CROSS-RESISTANCE BETWEEN AZT, DDL AND OTHER ANTIRETROVIRAL DRUGS IN PRIMARY ISOLATES OF HIV-1

被引：10

作者：

COX, SW

APERIA, K

SANDSTROM, E

HOLMBERG, V

MORFELDTMANSON, L

BROSTROM, C

WAHREN, B

ALBERT, J

机构：

[1] HUDDINGE HOSP,DEPT INFECT DIS,S-14186 HUDDINGE,SWEDEN

[2] DANDERYD HOSP,DEPT INFECT DIS,S-18288 DANDERYD,SWEDEN

[3] SODER SJUKHUSET,DEPT DERMATOVENEREOL,S-11883 STOCKHOLM,SWEDEN

[4] KAROLINSKA INST,DEPT CLIN VIROL,S-14186 HUDDINGE,SWEDEN

来源：

ANTIVIRAL CHEMISTRY & CHEMOTHERAPY | 1994年 / 5卷 / 01期

关键词：

D O I：

10.1177/095632029400500102

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Primary isolates of human immunodeficiency virus type 1 (HIV-1) were tested for sensitivity to 3'-azido-3'-deoxythymidine (AZT), 3'-fluoro-3'-deoxythymidine (FLT), 2',3'-dideoxyinosine (ddl), 2',3'-dideoxycytidine (ddC), and phosphonoformate (PFA) in peripheral blood mononuclear cells (PBMC). Forty-eight isolates from HIV-1-infected patients treated with AZT for various lengths of time were investigated. More than half of the patients harboured virus resistant to AZT after treatment. There was no correlation between resistance and length of therapy. A significant correlation between resistance to AZT and reduced susceptibility to ddl and ddC was apparent. These results indicate that development of resistance to AZT is common in patients treated with AZT and may be associated with reduced sensitivity to ddl and ddC.

引用

收藏

页码：7 / 12

页数：6

相关论文

共 24 条

[1] SIMPLE, SENSITIVE, AND SPECIFIC DETECTION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 IN CLINICAL SPECIMENS BY POLYMERASE CHAIN-REACTION WITH NESTED PRIMERS [J].

ALBERT, J ;

FENYO, EM .

JOURNAL OF CLINICAL MICROBIOLOGY, 1990, 28 (07) :1560-1564

[2] PERSISTENCE OF AZIDOTHYMIDINE-RESISTANT HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 RNA GENOTYPES IN POSTTREATMENT SERA [J].

ALBERT, J ;

WAHLBERG, J ;

LUNDEBERG, J ;

COX, S ;

SANDSTROM, E ;

WAHREN, B ;

UHLEN, M .

JOURNAL OF VIROLOGY, 1992, 66 (09) :5627-5630

[3] ORDERED APPEARANCE OF ZIDOVUDINE RESISTANCE MUTATIONS DURING TREATMENT OF 18 HUMAN IMMUNODEFICIENCY VIRUS-POSITIVE SUBJECTS [J].

BOUCHER, CAB ;

OSULLIVAN, E ;

MULDER, JW ;

RAMAUTARSING, C ;

KELLAM, P ;

DARBY, G ;

LANGE, JMA ;

GOUDSMIT, J ;

LARDER, BA .

JOURNAL OF INFECTIOUS DISEASES, 1992, 165 (01) :105-110

[4] HIV-1 BIOLOGICAL PHENOTYPE AND THE DEVELOPMENT OF ZIDOVUDINE RESISTANCE IN RELATION TO DISEASE PROGRESSION IN ASYMPTOMATIC INDIVIDUALS DURING TREATMENT [J].

BOUCHER, CAB ;

LANGE, JMA ;

MIEDEMA, FF ;

WEVERLING, GJ ;

KOOT, M ;

MULDER, JW ;

GOUDSMIT, J ;

KELLAM, P ;

LARDER, BA ;

TERSMETTE, M .

AIDS, 1992, 6 (11) :1259-1264

[5] HIV-1 SENSITIVITY TO ZIDOVUDINE AND CLINICAL OUTCOME [J].

BOUCHER, CAB ;

LANGE, JMA .

LANCET, 1992, 339 (8793) :626-626

[6] THE EFFICACY OF AZIDOTHYMIDINE (AZT) IN THE TREATMENT OF PATIENTS WITH AIDS AND AIDS-RELATED COMPLEX - A DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL [J].

FISCHL, MA ;

RICHMAN, DD ;

GRIECO, MH ;

GOTTLIEB, MS ;

VOLBERDING, PA ;

LASKIN, OL ;

LEEDOM, JM ;

GROOPMAN, JE ;

MILDVAN, D ;

SCHOOLEY, RT ;

JACKSON, GG ;

DURACK, DT ;

KING, D .

NEW ENGLAND JOURNAL OF MEDICINE, 1987, 317 (04) :185-191

[7] INVITRO SELECTION OF VARIANTS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 RESISTANT TO 3'-AZIDO-3'-DEOXYTHYMIDINE AND 2',3'-DIDEOXYINOSINE [J].

GAO, Q ;

GU, ZX ;

PARNIAK, MA ;

LI, XG ;

WAINBERG, MA .

JOURNAL OF VIROLOGY, 1992, 66 (01) :12-19

[8] NOVEL MUTATION IN THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE GENE THAT ENCODES CROSS-RESISTANCE TO 2',3'-DIDEOXYINOSINE AND 2',3'-DIDEOXYCYTIDINE [J].

GU, ZX ;

QING, G ;

LI, XG ;

PARNIAK, MA ;

WAINBERG, MA .

JOURNAL OF VIROLOGY, 1992, 66 (12) :7128-7135

[9]

KAHN J, 1992, NEW ENGL J MED, V5327, P581

[10] STRUCTURE-ACTIVITY-RELATIONSHIPS OF FLUORINATED NUCLEOSIDE ANALOGS AND THEIR SYNERGISTIC EFFECT IN COMBINATION WITH PHOSPHONOFORMATE AGAINST HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 [J].

KOSHIDA, R ;

COX, S ;

HARMENBERG, J ;

GILLJAM, G ;

WAHREN, B .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (12) :2083-2088