CROSS-RESISTANCE BETWEEN AZT, DDL AND OTHER ANTIRETROVIRAL DRUGS IN PRIMARY ISOLATES OF HIV-1

被引：10

作者：

COX, SW

APERIA, K

SANDSTROM, E

HOLMBERG, V

MORFELDTMANSON, L

BROSTROM, C

WAHREN, B

ALBERT, J

机构：

[1] HUDDINGE HOSP,DEPT INFECT DIS,S-14186 HUDDINGE,SWEDEN

[2] DANDERYD HOSP,DEPT INFECT DIS,S-18288 DANDERYD,SWEDEN

[3] SODER SJUKHUSET,DEPT DERMATOVENEREOL,S-11883 STOCKHOLM,SWEDEN

[4] KAROLINSKA INST,DEPT CLIN VIROL,S-14186 HUDDINGE,SWEDEN

来源：

ANTIVIRAL CHEMISTRY & CHEMOTHERAPY | 1994年 / 5卷 / 01期

关键词：

D O I：

10.1177/095632029400500102

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Primary isolates of human immunodeficiency virus type 1 (HIV-1) were tested for sensitivity to 3'-azido-3'-deoxythymidine (AZT), 3'-fluoro-3'-deoxythymidine (FLT), 2',3'-dideoxyinosine (ddl), 2',3'-dideoxycytidine (ddC), and phosphonoformate (PFA) in peripheral blood mononuclear cells (PBMC). Forty-eight isolates from HIV-1-infected patients treated with AZT for various lengths of time were investigated. More than half of the patients harboured virus resistant to AZT after treatment. There was no correlation between resistance and length of therapy. A significant correlation between resistance to AZT and reduced susceptibility to ddl and ddC was apparent. These results indicate that development of resistance to AZT is common in patients treated with AZT and may be associated with reduced sensitivity to ddl and ddC.

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页码：7 / 12

页数：6

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