DBI MESSENGER-RNA IS EXPRESSED IN ENDOCRINE PANCREAS AND ITS POSTTRANSLATIONAL PRODUCT DBI33-50 INHIBITS INSULIN RELEASE

被引：6

作者：

BORBONI, P

MAGNATERRA, R

PORZIO, O

FUSCO, A

SESTI, G

BERTOLI, A

LAURO, R

MARLIER, LNJL

机构：

[1] Department of Internal Medicine, University of Rome 'Tor Vergata', Rome

来源：

ENDOCRINE | 1995年 / 3卷 / 04期

关键词：

DBI; ISLETS OF LANGERHANS; INSULINOMA; GENE EXPRESSION; MBR; GABA(A) RECEPTOR; INSULIN SECRETION;

D O I：

10.1007/BF03021404

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It has been previously demonstrated that DBI is present in endocrine pancreas and it is able to inhibit insulin release in isolated rat islets. Its mechanism of action has been investigated, demonstrating the possible involvement of cAMP and ATP-dependent K+ channels. DBI33-50, a post-translational product of DBI, is also able to inhibit insulin release, but its action has not been characterized. In the present study, we have investigated the presence of DBI mRNA in pancreas, islets and cultured beta cells. The possible mechanism of action of DBI33-50 and the involvement of BZ/GABA(A) receptors has been studied.

引用

页码：267 / 271

页数：5

共 43 条

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