HISTAMINE AND PROSTANOID RECEPTORS ON GLIAL-CELLS

被引：36

作者：

INAGAKI, N ^{[1
]}

WADA, H ^{[1
]}

机构：

[1] SUNTORY RES CTR, SHIMAMOTO, OSAKA 618, JAPAN

来源：

GLIA | 1994年 / 11卷 / 02期

关键词：

H-1-RECEPTOR; H-2-RECEPTOR; PROSTAGLANDIN; THROMBOXANE; ASTROCYTE; OLIGODENDROCYTE;

D O I：

10.1002/glia.440110205

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Glial cells in vitro express at least two types (H-1 and H-2) of histamine receptors and three types (EP, FP, and TP) of prostanoid receptors. The receptors expressed by glial cells differ according to the cell type and source in the brain. Furthermore primary astrocytes of same type derived from the same brain region are composed of heterogeneous subpopulations expressing different subsets of receptors. Fura-2 based Ca2+ microscopy revealed that astrocyte processes are important sites for histamine-induced Ca2+ signalling. Histamine and prostanoid receptors on glial cells may play important roles in the actions of histamine and prostanoids in the central nervous system. (C) 1994 Wiley-Liss, Inc.

引用

页码：102 / 109

页数：8

共 90 条

[21] MOLECULAR MECHANISMS OF SLEEP-WAKE REGULATION - ROLES OF PROSTAGLANDIN-D2 AND PROSTAGLANDIN-E2 [J].