INTERLEUKIN-1 INCREASES THE PRODUCTION OF ENDOTHELIN-1 BY CULTURED ENDOTHELIAL-CELLS

被引：275

作者：

YOSHIZUMI, M ^{[1
]}

KURIHARA, H ^{[1
]}

MORITA, T ^{[1
]}

YAMASHITA, T ^{[1
]}

OHHASHI, Y ^{[1
]}

SUGIYAMA, T ^{[1
]}

TAKAKU, F ^{[1
]}

YANAGISAWA, M ^{[1
]}

MASAKI, T ^{[1
]}

YAZAKI, Y ^{[1
]}

机构：

[1] UNIV TSUKUBA,INST BASIC MED SCI,SAKURA,IBARAKI 30031,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 166卷 / 01期

关键词：

D O I：

10.1016/0006-291X(90)91948-R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We examined the effect of human recombinant interleukin 1 (IL-1) on the production of endothelin-1 by cultured porcine endothelial cells. The induction of endothelin-1 mRNA began within 1 hr of exposure to IL-1, showed twin peaks at 4 and 24 hr, and declined thereafter. Enzyme-linked immunosorbent assay revealed that the amount of endothelin-1 peptide in conditioned media was also increased by IL-1 in a dose- and time-dependent manner. Our results suggested that IL-1, a macrophage-derived cytokine, may affect the contraction and proliferation of vascular smooth muscle cells by stimulating the production of endothelin by endothelial cells. © 1990.

引用

页码：324 / 329

页数：6

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