POTENTIATION OF YAWNING RESPONSES TO THE DOPAMINE RECEPTOR AGONISTS B-HT 920 AND SND 919 BY PINDOLOL IN THE RAT

被引:15
作者
YAMADA, K
MATSUMOTO, S
NAGASHIMA, M
SHIRAKAWA, K
FURUKAWA, T
机构
[1] FUKUOKA UNIV,SCH MED,BIODYNAM RES LAB,FUKUOKA 81401,JAPAN
[2] FUKUOKA UNIV,SCH MED,DEPT OBSTET & GYNECOL,FUKUOKA 81401,JAPAN
关键词
β-adrenoceptors; B-HT; 920; dopaminergic neurons; pindolol; SND; 919; Yawning;
D O I
10.1007/BF01250996
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Subcutaneous injection of B-HT 920, a dopamine D2-receptor agonist, in doses ranging from 5 to 100μg/kg, induced yawning behavior in rats. Yawning was also elicited by low doses (25-500 μg/kg sc) of SND 919, a newly synthesized dopamine receptor agonist. The yawning evoked by B-HT 920 or SND 919 was increased by the β-adrenoceptor antagonist pindolol (20mg/kg ip) which alone did not induce yawning. Stereotyped behavior did not appear after B-HT 920 or SND 919 given alone or in combination with pindolol. The results suggest that SND 919 as well as B-HT 920 has stimulatory activity at dopamine D2-receptors, and that pindolol may exert its enhancement of the yawning response to dopamine receptor agonists via blockade of β-adrenoceptors. © 1990 Springer-Verlag.
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页码:19 / 24
页数:6
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