POTENTIATION OF YAWNING RESPONSES TO THE DOPAMINE RECEPTOR AGONISTS B-HT 920 AND SND 919 BY PINDOLOL IN THE RAT

Subcutaneous injection of B-HT 920, a dopamine D2-receptor agonist, in doses ranging from 5 to 100μg/kg, induced yawning behavior in rats. Yawning was also elicited by low doses (25-500 μg/kg sc) of SND 919, a newly synthesized dopamine receptor agonist. The yawning evoked by B-HT 920 or SND 919 was increased by the β-adrenoceptor antagonist pindolol (20mg/kg ip) which alone did not induce yawning. Stereotyped behavior did not appear after B-HT 920 or SND 919 given alone or in combination with pindolol. The results suggest that SND 919 as well as B-HT 920 has stimulatory activity at dopamine D2-receptors, and that pindolol may exert its enhancement of the yawning response to dopamine receptor agonists via blockade of β-adrenoceptors. © 1990 Springer-Verlag.