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POTENTIATION OF YAWNING RESPONSES TO THE DOPAMINE RECEPTOR AGONISTS B-HT 920 AND SND 919 BY PINDOLOL IN THE RAT
被引:15
作者
:
YAMADA, K
论文数:
0
引用数:
0
h-index:
0
机构:
FUKUOKA UNIV,SCH MED,BIODYNAM RES LAB,FUKUOKA 81401,JAPAN
YAMADA, K
MATSUMOTO, S
论文数:
0
引用数:
0
h-index:
0
机构:
FUKUOKA UNIV,SCH MED,BIODYNAM RES LAB,FUKUOKA 81401,JAPAN
MATSUMOTO, S
NAGASHIMA, M
论文数:
0
引用数:
0
h-index:
0
机构:
FUKUOKA UNIV,SCH MED,BIODYNAM RES LAB,FUKUOKA 81401,JAPAN
NAGASHIMA, M
SHIRAKAWA, K
论文数:
0
引用数:
0
h-index:
0
机构:
FUKUOKA UNIV,SCH MED,BIODYNAM RES LAB,FUKUOKA 81401,JAPAN
SHIRAKAWA, K
FURUKAWA, T
论文数:
0
引用数:
0
h-index:
0
机构:
FUKUOKA UNIV,SCH MED,BIODYNAM RES LAB,FUKUOKA 81401,JAPAN
FURUKAWA, T
机构
:
[1]
FUKUOKA UNIV,SCH MED,BIODYNAM RES LAB,FUKUOKA 81401,JAPAN
[2]
FUKUOKA UNIV,SCH MED,DEPT OBSTET & GYNECOL,FUKUOKA 81401,JAPAN
来源
:
JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION
|
1990年
/ 79卷
/ 1-2期
关键词
:
β-adrenoceptors;
B-HT;
920;
dopaminergic neurons;
pindolol;
SND;
919;
Yawning;
D O I
:
10.1007/BF01250996
中图分类号
:
Q189 [神经科学];
学科分类号
:
071006 ;
摘要
:
Subcutaneous injection of B-HT 920, a dopamine D2-receptor agonist, in doses ranging from 5 to 100μg/kg, induced yawning behavior in rats. Yawning was also elicited by low doses (25-500 μg/kg sc) of SND 919, a newly synthesized dopamine receptor agonist. The yawning evoked by B-HT 920 or SND 919 was increased by the β-adrenoceptor antagonist pindolol (20mg/kg ip) which alone did not induce yawning. Stereotyped behavior did not appear after B-HT 920 or SND 919 given alone or in combination with pindolol. The results suggest that SND 919 as well as B-HT 920 has stimulatory activity at dopamine D2-receptors, and that pindolol may exert its enhancement of the yawning response to dopamine receptor agonists via blockade of β-adrenoceptors. © 1990 Springer-Verlag.
引用
收藏
页码:19 / 24
页数:6
相关论文
共 22 条
[21]
YAMADA K, 1987, JPN J PHARMACOL, V43, pP43
[22]
YAMADA K, 1989, IN PRESS NAUNYN SCHM
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共 22 条
[21]
YAMADA K, 1987, JPN J PHARMACOL, V43, pP43
[22]
YAMADA K, 1989, IN PRESS NAUNYN SCHM
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