INDUCTION OF GROWTH ARREST BY A TEMPERATURE-SENSITIVE P53 MUTANT IS CORRELATED WITH INCREASED NUCLEAR-LOCALIZATION AND DECREASED STABILITY OF THE PROTEIN

被引：183

作者：

GINSBERG, D ^{[1
]}

MICHAELMICHALOVITZ, D ^{[1
]}

GINSBERG, D ^{[1
]}

OREN, M ^{[1
]}

机构：

[1] WEIZMANN INST SCI,DEPT CHEM IMMUNOL,IL-76100 REHOVOT,ISRAEL

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1991年 / 11卷 / 01期

关键词：

D O I：

10.1128/MCB.11.1.582

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A temperature-sensitive mutant of p53, p53Val-135, was found to be able to arrest cell proliferation when overexpressed at 32.5-degrees-C. While much of the protein was cytoplasmic in cells proliferating at 37.5-degrees-C, it became predominantly nuclear at 32.5-degrees-C. Concomitantly, p53Val-135 became destabilized, although not to the extent seen in primary fibroblasts.

引用

页码：582 / 585

页数：4

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