COCHINMICINS, NOVEL AND POTENT CYCLODEPSIPEPTIDE ENDOTHELIN ANTAGONISTS FROM A MICROBISPORA SP .1. PRODUCTION, ISOLATION, AND CHARACTERIZATION

被引：30

作者：

LAM, YKT

WILLIAMS, DL

SIGMUND, JM

SANCHEZ, M

GENILLOUD, O

KONG, YL

STEVENSMILES, S

HUANG, LY

GARRITY, GM

机构：

[1] MERCK RES LABS,W POINT,PA 19486

[2] MERCK SHARP & DOHME ESPANA SA,E-28027 MADRID,SPAIN

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 11期

关键词：

D O I：

10.7164/antibiotics.45.1709

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cochinmicins I II, Ill are novel peptolides produced in submerged-fermentation cultures of Microbispora sp. ATCC 55140. These closely related compounds are separated by HPLC and are novel competitive endothelin antagonists. Cochinmicins II and III are stereoisomeric to each other. Cochinmicin I is the deschloro analog of cochinmicin III.

引用

页码：1709 / 1716

页数：8

共 15 条

[1] COMPETITIVE INTERACTION BETWEEN ENDOTHELIN AND SARAFOTOXIN - BINDING AND PHOSPHOINOSITIDES HYDROLYSIS IN RAT ATRIA AND BRAIN [J].