DO PYRIMIDINE DIMER YIELDS CORRELATE WITH ERYTHEMA INDUCTION IN HUMAN SKIN IRRADIATED INSITU WITH ULTRAVIOLET-LIGHT (275-365NM)

被引：28

作者：

HACHAM, H

FREEMAN, SE

GANGE, RW

MAYTUM, DJ

SUTHERLAND, JC

SUTHERLAND, BM

机构：

[1] BROOKHAVEN NATL LAB, DEPT BIOL, UPTON, NY 11973 USA

[2] HARVARD UNIV, SCH MED, DEPT DERMATOL, WELLMAN LABS, BOSTON, MA 02115 USA

来源：

PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1991年 / 53卷 / 04期

关键词：

D O I：

10.1111/j.1751-1097.1991.tb03671.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ultraviolet radiation produces erythema in human skin, and damages the DNA of living cells in skin. Previous work showed that broad-band UV-B (290-320 nm) radiation produced higher levels of cyclobutyl pyrimidine dimers in DNA of individuals with high UV-B sensitivity (low minimal erythema dose) than in subjects of low UV-B sensitivity [Freeman et al. (1986) J. Invest. Dermatol., 86, 34-36]. We examined the relationship between erythema induction and dimer yields in DNA of human skin irradiated in situ with narrow band radiation spanning the wavelength range 275-365 nm. We find that, in general, higher dimer yields are produced per incident photon in volunteers with higher susceptibility to erythema induced by radiation of the same wavelength.

引用

页码：559 / 563

页数：5