TELOMERE POSITIONAL EFFECTS AND THE REGULATION OF CELLULAR SENESCENCE

被引：237

作者：

WRIGHT, WE

SHAY, JW

机构：

[1] Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75235-9039

来源：

TRENDS IN GENETICS | 1992年 / 8卷 / 06期

关键词：

D O I：

10.1016/0168-9525(92)90232-S

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Normal cells have a limited capacity to proliferate but the molecular clock that regulates the onset of cellular senescence remains unidentified. The ends of chromosomes - telomeres - have been shown to shorten progressively with age in normal cells. Here, we present a working model of how telomeric shortening may induce programmed changes in the regulation of cellular proliferation.

引用

页码：193 / 197

页数：5

共 32 条

[1] MODIFIERS OF POSITION EFFECT ARE SHARED BETWEEN TELOMERIC AND SILENT MATING-TYPE LOCI IN SACCHAROMYCES-CEREVISIAE
APARICIO, OM
BILLINGTON, BL
GOTTSCHLING, DE
[J]. CELL, 1991, 66 (06) : 1279 - 1287
[2] STRUCTURE AND FUNCTION OF TELOMERES
BLACKBURN, EH
[J]. NATURE, 1991, 350 (6319) : 569 - 573
[3] COOKE HJ, 1986, COLD SPRING HARB SYM, V51, P213, DOI 10.1101/SQB.1986.051.01.026
[4] COUNTER CM, IN PRESS EMBO J
[5] SV40 LARGE TUMOR-ANTIGEN FORMS A SPECIFIC COMPLEX WITH THE PRODUCT OF THE RETINOBLASTOMA SUSCEPTIBILITY GENE
DECAPRIO, JA
LUDLOW, JW
FIGGE, J
SHEW, JY
HUANG, CM
LEE, WH
MARSILIO, E
PAUCHA, E
LIVINGSTON, DM
[J]. CELL, 1988, 54 (02) : 275 - 283
[6] POSITION EFFECT VARIEGATION IN DROSOPHILA - TOWARDS A GENETICS OF CHROMATIN ASSEMBLY
EISSENBERG, JC
[J]. BIOESSAYS, 1989, 11 (01) : 14 - 17
[7] Finch CE, 1990, LONGEVITY SENESCENCE
[8] POSITION EFFECT AT SACCHAROMYCES-CEREVISIAE TELOMERES - REVERSIBLE REPRESSION OF POL-II TRANSCRIPTION
GOTTSCHLING, DE
APARICIO, OM
BILLINGTON, BL
ZAKIAN, VA
[J]. CELL, 1990, 63 (04) : 751 - 762
[9] GUOLIANG Y, 1990, NATURE, V344, P126
[10] COOPERATIVE EFFECT OF ANTISENSE-RB AND ANTISENSE-P53 OLIGOMERS ON THE EXTENSION OF LIFE-SPAN IN HUMAN-DIPLOID FIBROBLASTS, TIG-1
HARA, E
TSURUI, H
SHINOZAKI, A
NAKADA, S
ODA, K
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 179 (01) : 528 - 534

← 1 2 3 4 →