TOWARDS CLONING THE FAMILIAL BREAST OVARIAN-CANCER GENE ON CHROMOSOME-17

被引：8

作者：

BROWN, MA

SOLOMON, E

机构：

[1] Imperial Cancer Research Fund, London

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1994年 / 4卷 / 03期

关键词：

D O I：

10.1016/0959-437X(94)90033-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The past year has seen a great deal of excitement in the field of breast cancer genetics. Since linkage of the familial breast-ovarian cancer gene (BRCA1) to chromosome 17, the critical region has been narrowed to 1.0-1.5 Mb by recombination studies, a detailed physical map has been constructed and much of the region has been cloned in yeast artificial chromosome, bacteriophage P1 and cosmid vectors. The focus now lies on identifying the genes housed within the BRCA1 region and scanning them for oncogenic mutations.

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页码：439 / 445

页数：7

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