INTERLEUKINS (IL)-1 AND IL-2 CONTROL IL-2 RECEPTOR-ALPHA AND RECEPTOR-BETA EXPRESSION IN IMMATURE THYMOCYTES

被引:21
作者
WILSON, A
CORTHESY, P
REICHENBACH, P
MACDONALD, HR
NABHOLZ, M
机构
[1] SWISS INST EXPTL CANC RES,CH-1066 EPALINGES,SWITZERLAND
[2] EPALINGES & SWISS INST EXPTL CANC RES,EPALINGES,SWITZERLAND
关键词
INTERLEUKIN-2; RECEPTOR; THYMOCYTES; GENE EXPRESSION; INTERLEUKIN-1;
D O I
10.1002/eji.1830240802
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Functional high-affinity interleukin-2 receptors (IL-2R) contain three transmembrane proteins, IL-2R alpha, beta and gamma. We have investigated the expression of IL-2R alpha and beta genes in immature mouse thymocytes. Previous work has shown that during differentiation these cells transiently express IL-2R alpha on their surface. Stimulation of IL-2R alpha(+) and IL-2R alpha(-) immature thymocytes with phorbol 12-myristate 13-acetate and calcium ionophore induces synthesis of IL-2R alpha and IL-2R beta mRNA. Most of this response depends on autocrine stimulation by IL-2. IL-1 synergizes with IL-2 to induce a 120-fold increase in IL-2R alpha mRNA and a 14-fold increase in IL-2R beta mRNA levels. A large proportion of the stimulated cells contains both transcripts. These interleukins do not induce any differentiation to more mature phenotypes. Collectively, these results show that IL-2 plays a major role in the regulation of IL-2R expression in normal immature thymocytes. We suggest that this response to interleukins may be part of a homeostatic mechanism to increase the production of immature thymocytes during stress.
引用
收藏
页码:1729 / 1735
页数:7
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