The SRF and MCM1 transcription factors

被引:98
作者
Treisman, Richard [1 ]
Ammerer, Gustav [2 ,3 ,4 ]
机构
[1] Imperial Canc Res Fund, POB 123, London WC2A 3PX, England
[2] Forschungsinst Mol Pathol, IMP, A-1090 Vienna, Austria
[3] Univ Vienna, Inst Algemeine Biochem, A-1090 Vienna, Austria
[4] Univ Vienna, Ludwig Boltzmann Forsch Stelle, A-1090 Vienna, Austria
关键词
D O I
10.1016/S0959-437X(05)80277-1
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The mammalian transcription factor SRF (serum-response factor) and the related Saccharomyces cerevisiae transcription factor MCMI are the prototypes of a new class of dimeric DNA-binding proteins. Their function is regulated in part by the interactions of their DNA-binding domains with accessory proteins. Recent work has advanced the functional characterization of the contributions of SRF and MCMI, and their accessory proteins to transcriptional activation.
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页码:221 / 226
页数:6
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