COMPRESSIONAL BEHAVIOR OF AN AGGLOMERATED CELLULOSE POWDER

被引:13
作者
PESONEN, T
PARONEN, P
机构
[1] Department of Pharmaceutical, Technology University of Kuopio, 70211, Kuopio
关键词
D O I
10.3109/03639049009114905
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The ability of an agglomerated cellulose powder to total and plastic deformation was evaluated and compared with those of Avicel PH 101, Emcocel and an experimental depolymerized cellulose powder. The elastic recovely of compressed cellulose tablets was also measured. The effects of deformation of the material during the tableting process and recovery of tablet after maximum compression on the mechanical strength of tablets were also discussed. The apparent net work done into tablets during compression as well as the yield pressures to total and plastic deformation, determined from the Heckel treatment, showed no great differences between the agglomerated cellulose powder and the other cellulose powders. Thus all the cellulose materials studied had rather similar ability to total, i.e. elastic and plastic, deformation and to permanent, i.e. pure plastic, deformation. The obvious fragmentation of the agglomerated cellulose powder already at low compressional pressure, however, seemed to be advantageous for the formation of strong compacts. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
引用
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页码:591 / 612
页数:22
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