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ALCOHOL AND ALDEHYDE DEHYDROGENASE

被引：90
作者：
EHRIG, T
BOSRON, WF
LI, TK
机构：
[1] INDIANA UNIV,SCH MED,DEPT BIOCHEM,INDIANAPOLIS,IN 46202
[2] INDIANA UNIV,SCH MED,DEPT MED,INDIANAPOLIS,IN 46202
来源：
ALCOHOL AND ALCOHOLISM | 1990年 / 25卷 / 2-3期
关键词：
D O I：
10.1093/oxfordjournals.alcalc.a044985
中图分类号：
R194 [卫生标准、卫生检查、医药管理];
学科分类号：
摘要：
The enzymes mainly responsible for ethanol degradation in humans are liver alcohol dehydrogenases (ADH) and aldehyde dehydrogenases (ALDH). Polymorphisms occur in both enzymes, with marked differences in the steady-state kinetic constants. The Km-values for ethanol of ADH isoenzymes relevant for alcohol degradation range from 49 μM to 36 μM, and the Vmax-values from 0.6 to 10 U/mg. Expression of an inactive form of the ALDH2 isoenzyme, the so-called Oriental variant, results in impaired acetaldehyde metabolizing capacity. The differences in ethanol and acetaldehyde metabolizing activities of allelic enzyme forms may be responsible in part for the large variation in the alcohol metabolism rate in humans. Interindividual differences in the isoenzyme pattern may contribute to the genetically determined predisposition for excessive alcohol intake. © 1990 Medical Council on Alcoholism.
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页码：105 / 116
页数：12
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