ACTIVATION OF IMMEDIATE EARLY GENES AFTER ACUTE STRESS

被引：97

作者：

SCHREIBER, SS ^{[1
]}

TOCCO, G ^{[1
]}

SHORS, TJ ^{[1
]}

THOMPSON, RF ^{[1
]}

机构：

[1] UNIV SO CALIF,NEUROSCI PROGRAM,LOS ANGELES,CA 90089

来源：

NEUROREPORT | 1991年 / 2卷 / 01期

关键词：

IMMEDIATE EARLY GENES; INDUCTION; ACUTE STRESS; INSITU HYBRIDIZATION;

D O I：

10.1097/00001756-199101000-00004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

WE used in-situ hybridization to study the effect of acute stress on induction of the immediate early genes (IEGs), c-fos and zif/268, in the rat brain. After one hour of restraint plus intermittent tail shock, messenger RNA (mRNA) levels for both genes were significantly increased bilaterally in the neocortex, particularly in layers IV, V and VI, and in the CA1 region of the hippocampus. This regionally-specific response suggests that IEGs may have a role in the mediation of acute stress responses in the central nervous system.

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页码：17 / 20

页数：4

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