RELEASE OF ALZHEIMER AMYLOID PRECURSOR DERIVATIVES STIMULATED BY ACTIVATION OF MUSCARINIC ACETYLCHOLINE-RECEPTORS

被引：843

作者：

NITSCH, RM

SLACK, BE

WURTMAN, RJ

GROWDON, JH

机构：

[1] MASSACHUSETTS GEN HOSP,DEPT NEUROL,BOSTON,MA 02114

[2] HARVARD UNIV,SCH MED,BOSTON,MA 02115

来源：

SCIENCE | 1992年 / 258卷 / 5080期

关键词：

D O I：

10.1126/science.1411529

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Altered processing of the amyloid precursor protein (APP) is a central event in the formation of amyloid deposits in the brains of individuals with Alzheimer's disease. To investigate whether cellular APP processing is controlled by cell-surface neurotransmitter receptors, human embryonic kidney (293) cell lines were transfected with the genes for human brain muscarinic acetylcholine receptors. Stimulation of m1 and m3 receptor subtypes with carbachol increased the basal release of APP derivatives within minutes of treatment, indicating that preexisting APP is released in response to receptor activation. Receptor-activated APP release was blocked by staurosporine, suggesting that protein kinases mediate neurotransmitter receptor-controlled APP processing.

引用

页码：304 / 307

页数：4

共 33 条

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