PORTERS VERSUS ROWERS - A UNIFIED STOCHASTIC-MODEL OF MOTOR PROTEINS

被引:207
作者
LEIBLER, S
HUSE, DA
机构
[1] PRINCETON UNIV,DEPT MOLEC BIOL,PRINCETON,NJ 08544
[2] AT&T BELL LABS,MURRAY HILL,NJ 07974
关键词
D O I
10.1083/jcb.121.6.1357
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
We present a general phenomenological theory for chemical to mechanical energy transduction by motor enzymes which is based on the classical ''tight-coupling'' mechanism. The associated minimal stochastic model takes explicitly into account both ATP hydrolysis and thermal noise effects. It provides expressions for the hydrolysis rate and the sliding velocity, as functions of the ATP concentration and the number of motor enzymes. It explains in a unified way many results of recent in vitro motility assays. More importantly, the theory provides a natural classification scheme for the motors: it correlates the biochemical and mechanical differences between ''porters'' such as cellular kinesins or dyneins, and ''rowers'' such as muscular myosins or flagellar dyneins.
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页码:1357 / 1368
页数:12
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