MOLECULAR AND CELL BIOLOGICAL STUDIES OF AGING AND THEIR APPLICATION TO CONSIDERATIONS OF T-LYMPHOCYTE IMMUNOSENESCENCE

被引:41
作者
PAWELEC, G [1 ]
机构
[1] UNIV TUBINGEN, SCH MED, DEPT INTERNAL MED 2, TRANSPLANTAT IMMUNOL & IMMUNOHEMATOL SECT, TUBINGEN, GERMANY
关键词
IMMUNOSENESCENCE; T-LYMPHOCYTES; AGING;
D O I
10.1016/0047-6374(94)01549-2
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Evidence for positive regulation of ageing processes at the cell and molecular biology levels is reviewed and it is considered whether the immune system, as represented by the behaviour of lymphocytes-T, is similarly constrained.
引用
收藏
页码:1 / 32
页数:32
相关论文
共 224 条
  • [51] ISOLATION AND IDENTIFICATION OF AGING-RELATED CDNAS IN THE MOUSE
    FRIEDMAN, V
    WAGNER, J
    DANNER, DB
    [J]. MECHANISMS OF AGEING AND DEVELOPMENT, 1990, 52 (01) : 27 - 43
  • [52] PHYTOHEMAGGLUTININ INDUCED PROLIFERATION BY AGED LYMPHOCYTES - REDUCED EXPRESSION OF HIGH-AFFINITY INTERLEUKIN-2 RECEPTORS AND INTERLEUKIN-2 SECRETION
    FROELICH, CJ
    BURKETT, JS
    GUIFFAUT, S
    KINGSLAND, R
    BRAUNER, D
    [J]. LIFE SCIENCES, 1988, 43 (20) : 1583 - 1590
  • [53] SIGNAL-TRANSDUCTION CHANGES IN GRANULOCYTES AND LYMPHOCYTES WITH AGING
    FULOP, T
    [J]. IMMUNOLOGY LETTERS, 1994, 40 (03) : 259 - 268
  • [54] FUNG YKT, 1993, ONCOGENE, V8, P2659
  • [55] FUTREAL PA, 1991, ONCOGENE, V6, P1109
  • [56] GAMBLE DA, 1990, J IMMUNOL, V144, P3569
  • [57] CLONAL EXPANSIONS OF V-DELTA-1(+) AND V-DELTA-2(+) CELLS INCREASE WITH AGE AND LIMIT THE REPERTOIRE OF HUMAN GAMMA-DELTA T-CELLS
    GIACHINO, C
    GRANZIERO, L
    MODENA, V
    MAIOCCO, V
    LOMATER, C
    FANTINI, F
    LANZAVECCHIA, A
    MIGONE, N
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1994, 24 (08) : 1914 - 1918
  • [58] GILBERT KM, 1993, J IMMUNOL, V151, P1245
  • [59] IMMUNOLOGICAL STUDIES OF AGING - DECREASED PRODUCTION OF AND RESPONSE TO T-CELL GROWTH-FACTOR BY LYMPHOCYTES FROM AGED HUMANS
    GILLIS, S
    KOZAK, R
    DURANTE, M
    WEKSLER, ME
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1981, 67 (04) : 937 - 942
  • [60] IDENTIFICATION OF A HIGHLY ABUNDANT CDNA ISOLATED FROM SENESCENT WI-38 CELLS
    GIORDANO, T
    FOSTER, DN
    [J]. EXPERIMENTAL CELL RESEARCH, 1989, 185 (02) : 399 - 406