SYNTHESIS OF AN ENANTIOMERICALLY PURE INTERMEDIATE CONTAINING THE CD SUBSTRUCTURE OF TAXOL

被引:50
作者
ISAACS, RCA
DIGRANDI, MJ
DANISHEFSKY, SJ
机构
[1] Laboratory of Bio-Organic Chemisry, Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, New York, New York 10021
关键词
D O I
10.1021/jo00067a028
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A straightforward conversion of the (R)-(-)-Hajos-Parrish ketone 5 to oxetane 13 is reported. It is anticipated that intermediates related to this compound could be useful for the total synthesis of taxol.
引用
收藏
页码:3938 / 3941
页数:4
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