HISTAMINE-RECEPTOR CONTROL OF GASTRIC MICROVASCULATURE IN SHOCK

被引：35

作者：

LEVINE, BA ^{[1
]}

SCHWESINGER, WH ^{[1
]}

JONES, D ^{[1
]}

SIRINEK, KR ^{[1
]}

机构：

[1] USA,INST SURG RES,FT SAM HOUSTON,TX 78234

来源：

JOURNAL OF SURGICAL RESEARCH | 1979年 / 26卷 / 05期

关键词：

D O I：

10.1016/0022-4804(79)90046-5

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Control of gastric mucosal blood flow in hemorrhagic shock was investigated, in an anesthetized miniature swine model, using H1-receptor (diphenhydramine) and H2-receptor (cimetidine) antagonisms. The animals were divided into two experimental groups: (i) diphenhydramine treatment; and (ii) diphenhydramine plus cimetidine treatment. Results were compared to previously reported untreated controls and animals who received cimetidine alone. Conclusions reached were: (1) Histamine receptors in the gastric microvasculature do play a role in the control of mucosal blood flow during shock. (2) H2-Receptor antagonism, whether alone or in conjunction with H1-receptor antagonism, results in significant protection against a shock-related decrease in gastric mucosal blood flow. (3) H1-Receptor antagonism does not affect gastric mucosal blood flow in shock. © 1979.

引用

页码：532 / 539

页数：8

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